TIPIN

Across TCGA pan-cancer cohorts, TIPIN mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TIPIN data layer compared with 26 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TIPIN mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TIPIN expression acts as an unfavorable survival marker, although some lineages such as HNSC and LSCC show a favorable association.

HNSC, LSCC, and PDAC are the cancer types where TIPIN mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Median	II,III,IV	0.839	0.491	<.001	47	view →
LSCC	DFS	Tertile	II,III,IV	0.910	0.518	.001	25	view →
PDAC	DFS	Tertile	All	0.272	0.827	.024	23	view →
LUAD	DFS	Quartile	III,IV	0.947	0.286	.024	11	view →
CCRCC	DFS	Median	II,III,IV	0.482	1.000	.031	2	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TIPIN–HNSC (OS)

Open the HNSC breakdown →