TINAG

Across TCGA patient cohorts, TINAG mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TINAG-associated genes across cancer lineages are GATA6, Rad50, and Caspase-7-cleavedD198. Each is linked with TINAG in more than 1 cancer types. Because this analysis shows association rather than direction, both TINAG-to-partner and partner-to-TINAG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GATA6 grouped by TINAG-low versus TINAG-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TINAG→partner) and Y-score (partner→TINAG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GATA6 →	-0.119	-2.985	.032	.034	3	2
UCEC	Rad50 →	-0.187	-2.000	.028	.030	3	2
UCEC	Caspase-7-cleavedD198 →	+0.552	+2.341	.008	.003	3	2
SKCM	BRCA2 →	-0.190	-2.977	.009	.032	3	2
LUSC	Collagen-VI →	-0.258	-3.321	.031	.009	3	1
UCEC	14-3-3_beta →	-0.072	-1.973	.043	.029	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

GATA6 by TINAG expression — UCEC

Explore this box plot interactively →