TINAG

Across TCGA cell cohorts, TINAG mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible TINAG-associated genes across cancer lineages are MYF6, OR4E1, and CFC1B. Each is linked with TINAG in more than 1 cancer types. Because this analysis shows association rather than direction, both TINAG-to-partner and partner-to-TINAG results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MYF6 grouped by TINAG-low versus TINAG-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TINAG→partner) and Y-score (partner→TINAG) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	MYF6 →	+0.013	+4.906	<.001	.006	3	1
OESOPHAGUS	OR4E1 →	+0.016	+4.906	<.001	.006	3	1
SKIN	CFC1B →	+0.035	+4.022	<.001	.006	3	1
SKIN	RIT2 →	+0.020	+4.022	<.001	.006	3	1
SKIN	OR5A1 →	+0.010	+4.022	<.001	.006	3	1
SKIN	TOPAZ1 →	+0.006	+4.022	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

MYF6 by TINAG expression — OESOPHAGUS

Explore this box plot interactively →