TIMP3

Across TCGA pan-cancer cohorts, TIMP3 mass-spec protein is linked to patient survival in 8 of 34 cancer types, making it a survival-associated TIMP3 data layer compared with 28 for mass-spec protein and 6 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TIMP3 mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TIMP3 expression acts as an unfavorable survival marker, although some lineages such as CCRCC show a favorable association.

PDAC, LUAD, and COAD are the cancer types where TIMP3 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Median	All	0.317	0.496	.003	59	view →
LUAD	OS	Tertile	II,III,IV	0.378	0.951	<.001	32	view →
COAD	DFS	Median	II,III,IV	0.872	1.000	.012	24	view →
CCRCC	OS	Median	All	1.000	0.661	.008	16	view →
HNSC	OS	Quartile	IV	0.623	0.939	.005	10	view →
LSCC	DFS	Tertile	II,III,IV	0.542	0.896	.011	10	view →
UCEC	OS	Median	III,IV	0.466	0.915	.032	4	view →
GBM	DFS	Quartile	All	0.202	0.454	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 8 strongest of 8 lineages.

TIMP3–PDAC (DFS)

Open the PDAC breakdown →