TIMP3

Across TCGA pan-cancer cohorts, TIMP3 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TIMP3’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal papillary cell carcinoma (KIRP), where TIMP3 RNA is repressed in tumor relative to normal tissue. In most cancer types TIMP3 is over-expressed in tumor, although a few such as KIRP and KICH show the opposite, repressed pattern.

KIRP, KICH, and THCA are the cancer types where TIMP3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TIMP3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRP	Male	All	−2.757	<.001	11	view →
KICH	Male	All	−2.636	<.001	9	view →
THCA	All	II,III,IV	−1.718	<.001	9	view →
HNSC	Female	III,IV	+1.987	.001	8	view →
LUAD	Female	All	−1.511	<.001	8	view →
KIRC	Male	II,III,IV	−0.971	<.001	8	view →
UCEC	All	All	−2.607	<.001	6	view →
LUSC	Female	All	−2.268	<.001	6	view →
BRCA	All	All	−0.517	<.001	4	view →
STAD	Female	All	−1.601	.027	3	view →
PRAD	All	All	−0.869	<.001	2	view →
LIHC	All	All	+0.350	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TIMP3–KIRP

Open the KIRP breakdown →