TIMP3

Across TCGA patient cohorts, TIMP3 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIMP3-associated genes across cancer lineages are Notch1, p62 Lck ligand, and PDCD4. Each is linked with TIMP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMP3-to-partner and partner-to-TIMP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TIMP3-low versus TIMP3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMP3→partner) and Y-score (partner→TIMP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.178	+2.179	<.001	.001	3	2
UCEC	p62 Lck ligand →	+0.467	+4.087	<.001	<.001	3	2
UCEC	PDCD4 →	-0.528	-2.115	<.001	.016	3	2
UCEC	ATM →	-0.422	-1.807	.005	.025	3	2
UCEC	eIF4E →	+0.197	+3.598	.005	.001	3	1
UCEC	A-Raf_pS299 →	-0.108	-2.502	.007	.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

Notch1 by TIMP3 expression — UCEC

Explore this box plot interactively →