TIMP3

Across TCGA cell cohorts, TIMP3 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,502 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TIMP3-associated GO terms across cancer lineages are Negative regulation of response to endoplasmic reticulum stress, Viral process, and Protein stabilization. Each is linked with TIMP3 in more than 11 cancer types. Because this analysis shows association rather than direction, both TIMP3-to-partner and partner-to-TIMP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Negative regulation of response to endoplasmic reticulum stress grouped by TIMP3-low versus TIMP3-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMP3→partner) and Y-score (partner→TIMP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Negative regulation of response to endoplasmic reticulum stress →	+0.087	+1.969	<.001	.001	3	12
BREAST	Viral process →	+0.083	+3.670	.001	<.001	3	11
OESOPHAGUS	Protein stabilization →	+0.059	+2.734	.001	<.001	3	11
OESOPHAGUS	Positive regulation of protein catabolic process →	+0.048	+2.242	.001	.003	3	11
URINARY_TRACT	Cell-substrate junction organization →	+0.164	+3.038	<.001	.002	3	10
BONE	Endoplasmic reticulum to cytosol transport →	+0.114	+2.425	.008	.005	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,502 associations by consensus.

Negative regulation of response to endoplasmic reticulum stress by TIMP3 expression — LARGE_INTESTINE

Explore this box plot interactively →