TIMP3

Across TCGA cell cohorts, TIMP3 mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible TIMP3-associated genes across cancer lineages are GJA10, OR4K1, and LCE2B. Each is linked with TIMP3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMP3-to-partner and partner-to-TIMP3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GJA10 grouped by TIMP3-low versus TIMP3-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMP3→partner) and Y-score (partner→TIMP3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GJA10 →	+0.044	+4.212	.005	.007	3	1
LUNG_NSCLC_LUAD	OR4K1 →	+0.024	+5.813	<.001	<.001	3	1
LUNG_NSCLC_LUAD	LCE2B →	+0.029	+4.662	<.001	.005	3	1
LARGE_INTESTINE	OR4F4 →	+0.020	+4.273	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GJA10 by TIMP3 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →