TIMMDC1

Across TCGA patient cohorts, TIMMDC1 mutation is significantly associated with the RNA expression of many other genes, with 1,329 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIMMDC1-associated genes across cancer lineages are RNA5SP113, RNU6-299P, and RNU6-278P. Each is linked with TIMMDC1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TIMMDC1-to-partner and partner-to-TIMMDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP113 grouped by TIMMDC1-low versus TIMMDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMMDC1→partner) and Y-score (partner→TIMMDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP113 →	+0.561	+3.641	<.001	<.001	3	3
SKCM	RNU6-299P →	+0.340	+5.021	<.001	<.001	3	2
BRCA	RNU6-278P →	+0.272	+7.731	<.001	.009	3	2
LUAD	OR5T2 →	+0.073	+4.076	<.001	.004	3	2
LUAD	OR52J3 →	+0.030	+4.859	<.001	.004	3	2
LUAD	NDUFS5P5 →	+0.124	+4.330	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,329 associations by consensus.

RNA5SP113 by TIMMDC1 expression — UCEC

Explore this box plot interactively →