TIMMDC1

Across TCGA pan-cancer cohorts, TIMMDC1 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of TIMMDC1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TIMMDC1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TIMMDC1 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, BLCA, and LIHC are the cancer types where TIMMDC1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TIMMDC1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+0.903	<.001	12	view →
BLCA	All	III,IV	+0.791	<.001	10	view →
LIHC	Male	II,III,IV	+1.002	<.001	9	view →
THCA	Male	III,IV	−0.647	<.001	9	view →
LUSC	Female	All	+0.945	<.001	6	view →
BRCA	All	III,IV	+0.301	<.001	6	view →
CHOL	Male	All	+1.866	<.001	5	view →
KICH	All	All	−0.781	<.001	5	view →
LUAD	All	All	+0.220	.001	5	view →
STAD	All	II,III,IV	+0.434	.003	4	view →
KIRC	Male	II,III,IV	−0.380	<.001	4	view →
ESCA	All	All	+0.700	.007	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

TIMMDC1–HNSC

Open the HNSC breakdown →