TIMMDC1

Across TCGA patient cohorts, TIMMDC1 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIMMDC1-associated genes across cancer lineages are 14-3-3_beta, EGFR_pY1068, and Fibronectin. Each is linked with TIMMDC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMMDC1-to-partner and partner-to-TIMMDC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, 14-3-3_beta grouped by TIMMDC1-low versus TIMMDC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMMDC1→partner) and Y-score (partner→TIMMDC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	14-3-3_beta →	-0.112	-2.973	.020	.035	3	1
UCEC	EGFR_pY1068 →	-0.285	-2.459	.018	.020	3	1
UCEC	Fibronectin →	-0.343	-3.160	.031	.019	3	1
UCEC	Heregulin →	-0.168	-3.321	.004	.010	3	1
UCEC	INPP4B →	-0.473	-3.321	.002	.010	3	1
UCEC	Akt_pT308 →	+0.802	+2.999	.008	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

14-3-3_beta by TIMMDC1 expression — UCEC

Explore this box plot interactively →