TIMM9

Across TCGA patient cohorts, TIMM9 mutation is significantly associated with the total protein of many other genes, with 13 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIMM9-associated genes across cancer lineages are JNK_pT183_Y185, PCNA, and STAT3_pY705. Each is linked with TIMM9 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMM9-to-partner and partner-to-TIMM9 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by TIMM9-low versus TIMM9-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMM9→partner) and Y-score (partner→TIMM9) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.228	-3.156	.013	.020	3	1
UCEC	PCNA →	+0.303	+3.000	.010	.036	3	1
UCEC	STAT3_pY705 →	-0.515	-3.159	<.001	.019	3	1
UCEC	VHL →	-1.048	-3.169	.004	.020	3	1
UCEC	C-Raf →	+0.254	+3.000	.001	.036	3	1
UCEC	Gab2 →	+0.398	+3.169	.042	.020	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 13 associations by consensus.

JNK_pT183_Y185 by TIMM9 expression — UCEC

Explore this box plot interactively →