TIMM50

Across TCGA pan-cancer cohorts, TIMM50 mass-spec protein differs between tumor and matched normal tissue in 7 of 18 cancer types tested, making tumor–normal expression one of TIMM50’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TIMM50 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TIMM50 is over-expressed in tumor, although a few such as CCRCC show the opposite, repressed pattern.

COAD, PDAC, and CCRCC are the cancer types where TIMM50 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TIMM50 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Male	III,IV	+0.609	<.001	11	view →
PDAC	All	III,IV	+0.598	<.001	10	view →
CCRCC	Female	III,IV	−0.556	<.001	10	view →
LUAD	Male	II,III,IV	+0.519	<.001	9	view →
LSCC	Female	All	+0.696	<.001	8	view →
HNSC	Male	III,IV	+0.165	.007	4	view →
OV	All	All	+0.531	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 7 strongest of 7 lineages.

TIMM50–COAD

Open the COAD breakdown →