TIMM50

Across TCGA pan-cancer cohorts, TIMM50 RNA is linked to patient survival in 28 of 34 cancer types, making it the most broadly survival-associated TIMM50 data layer compared with 6 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher TIMM50 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TIMM50 expression acts as an unfavorable survival marker, although some lineages such as GBM and READ show a favorable association.

MESO, ACC, and LIHC are the cancer types where TIMM50 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.416	0.662	<.001	117	view →
ACC	DFS	Median	All	0.224	0.671	<.001	116	view →
LIHC	DFS	Quartile	All	0.420	0.626	<.001	45	view →
SKCM	OS	Tertile	All	0.263	0.383	<.001	43	view →
UVM	DFS	Tertile	All	0.623	0.895	.007	41	view →
UCEC	OS	Tertile	All	0.826	0.922	.002	40	view →
LUAD	OS	Median	All	0.292	0.413	.005	28	view →
KIRC	DFS	Median	III,IV	0.510	0.763	<.001	27	view →
OV	OS	Tertile	II,III,IV	0.779	0.889	.006	24	view →
KICH	DFS	Quartile	III,IV	0.026	0.763	.010	17	view →
GBM	DFS	Quartile	All	0.332	0.173	.002	17	view →
READ	OS	Median	III,IV	1.000	0.516	.018	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 28 lineages.

TIMM50–MESO (OS)

Open the MESO breakdown →