TIMM50

Across TCGA patient cohorts, TIMM50 mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIMM50-associated genes across cancer lineages are Ku80, Rictor_pT1135, and c-Met_pY1235. Each is linked with TIMM50 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMM50-to-partner and partner-to-TIMM50 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Ku80 grouped by TIMM50-low versus TIMM50-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMM50→partner) and Y-score (partner→TIMM50) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Ku80 →	+0.334	+3.009	.007	.019	3	1
UCEC	Rictor_pT1135 →	-0.193	-3.321	<.001	.010	3	1
UCEC	c-Met_pY1235 →	+0.095	+3.331	.014	.005	3	1
UCEC	JNK_pT183_Y185 →	-0.267	-3.000	.002	.036	2	1
UCEC	p62 Lck ligand →	+0.421	+2.817	.013	.036	2	1
UCEC	ATM →	-0.782	-3.321	<.001	.010	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Ku80 by TIMM50 expression — UCEC

Explore this box plot interactively →