TIMM44

Across TCGA patient cohorts, TIMM44 mutation is significantly associated with the total protein of many other genes, with 22 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIMM44-associated genes across cancer lineages are ERK2, EGFR_pY1068, and IGFBP2. Each is linked with TIMM44 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMM44-to-partner and partner-to-TIMM44 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ERK2 grouped by TIMM44-low versus TIMM44-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMM44→partner) and Y-score (partner→TIMM44) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ERK2 →	+0.243	+3.000	<.001	<.001	3	2
UCEC	EGFR_pY1068 →	-0.271	-2.584	.004	.001	3	1
UCEC	IGFBP2 →	-0.829	-2.000	<.001	.029	3	1
UCEC	JNK_pT183_Y185 →	-0.184	-2.700	.004	.006	3	1
UCEC	JNK2 →	+0.271	+2.087	<.001	.005	3	1
UCEC	Ku80 →	+0.253	+2.100	.005	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 22 associations by consensus.

ERK2 by TIMM44 expression — UCEC

Explore this box plot interactively →