TIMM44

Across TCGA pan-cancer cohorts, TIMM44 RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated TIMM44 data layer compared with 5 for mutation status and 7 for mass-spec protein.

The strongest signal is observed in kidney chromophobe (KICH), where higher TIMM44 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TIMM44 expression acts as an unfavorable survival marker, although some lineages such as SCLC and CESC show a favorable association.

KICH, UVM, and LGG are the cancer types where TIMM44 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Tertile	All	0.309	0.940	<.001	68	view →
UVM	DFS	Tertile	II,III,IV	0.283	0.754	<.001	57	view →
LGG	DFS	Median	All	0.283	0.494	<.001	49	view →
ACC	DFS	Median	All	0.285	0.651	<.001	46	view →
SCLC	OS	Tertile	All	0.764	0.486	.005	45	view →
LIHC	OS	Quartile	All	0.557	0.754	.002	43	view →
UCS	DFS	Median	IV	0.367	0.952	.001	36	view →
PRAD	DFS	Quartile	All	0.733	0.892	.006	24	view →
ESCA	DFS	Tertile	II,III,IV	0.321	0.568	<.001	23	view →
CESC	DFS	Quartile	II,III,IV	0.635	0.269	.005	22	view →
HNSC	OS	Tertile	IV	0.791	0.629	.004	18	view →
PAAD	DFS	Tertile	All	0.557	0.391	.015	17	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

TIMM44–KICH (OS)

Open the KICH breakdown →