TIMM44

Across TCGA cell cohorts, TIMM44 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,353 significant associations in total. SOFT_TISSUE shows the largest number of these associations.

The most reproducible TIMM44-associated GO terms across cancer lineages are Mitochondrial tRNA wobble uridine modification, Energy coupled proton transmembrane transport, against electrochemical gradient, and Electron transport coupled proton transport. Each is linked with TIMM44 in more than 16 cancer types. Because this analysis shows association rather than direction, both TIMM44-to-partner and partner-to-TIMM44 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Mitochondrial tRNA wobble uridine modification grouped by TIMM44-low versus TIMM44-high in LUNG_NSCLC_LUSC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMM44→partner) and Y-score (partner→TIMM44) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUSC	Mitochondrial tRNA wobble uridine modification →	+0.172	+1.006	<.001	<.001	3	17
BONE	Energy coupled proton transmembrane transport, against electrochemical gradient →	+0.125	+1.481	<.001	<.001	3	16
BONE	Electron transport coupled proton transport →	+0.125	+1.481	<.001	<.001	3	16
BONE	Cytoplasm protein quality control by the ubiquitin-proteasome system →	+0.168	+0.992	<.001	<.001	3	14
SKIN	Aminoacyl-tRNA metabolism involved in translational fidelity →	+0.126	+1.121	<.001	<.001	3	14
SOFT_TISSUE	Positive regulation of T-helper 17 cell lineage commitment →	+0.242	+1.177	<.001	<.001	3	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,353 associations by consensus.

Mitochondrial tRNA wobble uridine modification by TIMM44 expression — LUNG_NSCLC_LUSC

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