TIMM17B

Across TCGA patient cohorts, TIMM17B mutation is significantly associated with the total protein of many other genes, with 42 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIMM17B-associated genes across cancer lineages are Notch1, EGFR_pY1068, and ERK2. Each is linked with TIMM17B in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMM17B-to-partner and partner-to-TIMM17B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TIMM17B-low versus TIMM17B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMM17B→partner) and Y-score (partner→TIMM17B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.146	+2.179	.014	.034	3	2
UCEC	EGFR_pY1068 →	-0.367	-4.000	<.001	<.001	3	1
UCEC	ERK2 →	+0.233	+1.700	.004	.044	3	1
UCEC	ETS-1 →	+0.285	+3.169	.034	.019	3	1
UCEC	GAPDH →	+0.549	+2.321	.016	.034	3	1
UCEC	Heregulin →	-0.157	-2.700	.002	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

Notch1 by TIMM17B expression — UCEC

Explore this box plot interactively →