TIMM17A

Across TCGA patient cohorts, TIMM17A mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIMM17A-associated genes across cancer lineages are ACVRL1, JNK_pT183_Y185, and Rictor_pT1135. Each is linked with TIMM17A in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMM17A-to-partner and partner-to-TIMM17A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ACVRL1 grouped by TIMM17A-low versus TIMM17A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMM17A→partner) and Y-score (partner→TIMM17A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ACVRL1 →	-0.144	-3.150	.043	.019	3	1
UCEC	JNK_pT183_Y185 →	-0.212	-3.169	.016	.019	3	1
UCEC	Rictor_pT1135 →	-0.125	-3.321	.020	.010	3	1
UCEC	Annexin_VII →	-0.156	-3.321	.032	.010	3	1
UCEC	PCNA →	+0.321	+3.321	.004	.010	2	1
UCEC	Shc_pY317 →	-0.179	-3.000	.024	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

ACVRL1 by TIMM17A expression — UCEC

Explore this box plot interactively →