TIMM17A

Across TCGA pan-cancer cohorts, TIMM17A RNA differs between tumor and matched normal tissue in 16 of 18 cancer types tested, making tumor–normal expression one of TIMM17A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TIMM17A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TIMM17A is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

HNSC, LIHC, and STAD are the cancer types where TIMM17A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TIMM17A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+0.815	<.001	12	view →
LIHC	Male	II,III,IV	+1.500	<.001	9	view →
STAD	All	II,III,IV	+0.721	<.001	9	view →
THCA	Male	All	−0.461	<.001	9	view →
BRCA	All	III,IV	+1.107	<.001	8	view →
LUAD	Male	II,III,IV	+0.983	<.001	8	view →
BLCA	Female	III,IV	+0.554	<.001	8	view →
UCEC	All	All	+0.831	<.001	6	view →
CHOL	All	All	+1.531	<.001	5	view →
READ	All	II,III,IV	+0.929	.001	5	view →
KICH	All	All	−0.663	<.001	5	view →
LUSC	Male	All	+0.590	<.001	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 16 lineages.

TIMM17A–HNSC

Open the HNSC breakdown →