TIMM10

Across TCGA pan-cancer cohorts, TIMM10 RNA is linked to patient survival in 27 of 34 cancer types, making it the most broadly survival-associated TIMM10 data layer compared with 4 for mass-spec protein.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TIMM10 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TIMM10 expression acts as an unfavorable survival marker, although some lineages such as OV and KIRC show a favorable association.

HNSC, KICH, and UVM are the cancer types where TIMM10 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	DFS	Median	All	0.537	0.662	<.001	82	view →
KICH	DFS	Tertile	All	0.663	1.000	.003	51	view →
UVM	DFS	Median	All	0.536	0.887	.004	48	view →
ACC	DFS	Tertile	All	0.215	0.740	.001	26	view →
UCS	DFS	Median	IV	0.367	0.952	.001	24	view →
OV	OS	Quartile	IV	0.925	0.774	.014	20	view →
PRAD	DFS	Median	All	0.682	0.885	<.001	18	view →
KIRC	DFS	Tertile	All	0.722	0.505	.003	15	view →
LIHC	OS	Tertile	All	0.484	0.698	.004	15	view →
ESCA	OS	Median	II,III,IV	0.417	0.600	.022	11	view →
THYM	DFS	Quartile	II,III,IV	0.399	1.000	.005	11	view →
THCA	DFS	Tertile	All	0.894	0.728	.007	10	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 27 lineages.

TIMM10–HNSC (DFS)

Open the HNSC breakdown →