TIMD4

Across TCGA cell cohorts, TIMD4 mutation is significantly associated with the RNA expression of many other genes, with 633 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TIMD4-associated genes across cancer lineages are RNASE9, LCE1C, and OR5H8. Each is linked with TIMD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIMD4-to-partner and partner-to-TIMD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNASE9 grouped by TIMD4-low versus TIMD4-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIMD4→partner) and Y-score (partner→TIMD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	RNASE9 →	+0.022	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	LCE1C →	+0.079	+4.887	<.001	.009	3	1
LUNG_NSCLC_LUAD	OR5H8 →	+0.022	+5.662	<.001	.002	3	1
BLOOD_Leukemia	RS1 →	+0.156	+3.564	<.001	.003	3	1
BLOOD_Leukemia	ASZ1 →	+0.098	+3.567	.001	.003	3	1
BLOOD_Leukemia	DSG4 →	+0.027	+3.684	<.001	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 633 associations by consensus.

RNASE9 by TIMD4 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →