TIGD4

Across TCGA pan-cancer cohorts, TIGD4 Mutation is linked to patient survival in 9 of 34 cancer types, making it a survival-associated TIGD4 data layer compared with 27 for mass-spec protein.

The strongest signal is observed in lung squamous cell carcinoma (LUSC), where higher TIGD4 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TIGD4 expression acts as an unfavorable survival marker, although some lineages such as UCEC show a favorable association.

LUSC, UCEC, and COAD are the cancer types where TIGD4 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUSC	OS	Median	II,III,IV	0.001	0.733	<.001	30	view →
UCEC	DFS	Median	II,III,IV	0.933	0.303	.010	28	view →
COAD	OS	Median	All	0.117	0.809	<.001	18	view →
LIHC	DFS	Median	All	0.029	0.556	<.001	12	view →
LUAD	OS	Median	II,III,IV	0.017	0.710	<.001	12	view →
SKCM	OS	Median	III,IV	0.223	0.729	<.001	12	view →
PRAD	DFS	Median	All	0.085	0.774	<.001	6	view →
LGG	DFS	Median	All	0.110	0.826	<.001	3	view →
HNSC	OS	Median	All	0.195	0.686	.039	3	view →

Pink = unfavorable, green = favorable. Showing the 9 strongest of 9 lineages.

TIGD4–LUSC (OS)

Open the LUSC breakdown →