TIGD4

Across TCGA patient cohorts, TIGD4 mutation is significantly associated with the total protein of many other genes, with 56 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIGD4-associated genes across cancer lineages are GSK-3a-b_pS21_S9, JNK_pT183_Y185, and STAT3_pY705. Each is linked with TIGD4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIGD4-to-partner and partner-to-TIGD4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSK-3a-b_pS21_S9 grouped by TIGD4-low versus TIGD4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIGD4→partner) and Y-score (partner→TIGD4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GSK-3a-b_pS21_S9 →	+0.287	+1.523	.035	.008	3	2
UCEC	JNK_pT183_Y185 →	-0.186	-2.045	<.001	<.001	3	2
UCEC	STAT3_pY705 →	-0.381	-1.777	<.001	.002	3	2
UCEC	Cyclin-B1 →	+0.795	+2.378	<.001	<.001	3	2
UCEC	Cyclin-E2 →	+0.141	+2.058	.008	<.001	3	2
UCEC	14-3-3_beta →	-0.120	-2.558	<.001	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 56 associations by consensus.

GSK-3a-b_pS21_S9 by TIGD4 expression — UCEC

Explore this box plot interactively →