TIGD3

Across TCGA patient cohorts, TIGD3 mutation is significantly associated with the total protein of many other genes, with 35 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIGD3-associated genes across cancer lineages are Caspase-7-cleavedD198, Src_pY416, and eIF4E. Each is linked with TIGD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both TIGD3-to-partner and partner-to-TIGD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TIGD3-low versus TIGD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIGD3→partner) and Y-score (partner→TIGD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.656	+1.720	.002	.025	3	3
COAD	Src_pY416 →	+0.387	+2.820	.010	.035	3	2
UCEC	eIF4E →	+0.179	+1.925	.018	.005	3	2
UCEC	Ku80 →	+0.240	+1.939	.004	.003	3	2
UCEC	PRDX1 →	+0.159	+2.321	.032	.005	3	2
UCEC	Annexin-1 →	+0.541	+2.341	.004	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 35 associations by consensus.

Caspase-7-cleavedD198 by TIGD3 expression — UCEC

Explore this box plot interactively →