TIGD3

Across TCGA pan-cancer cohorts, TIGD3 RNA is linked to patient survival in 31 of 34 cancer types, making it the most broadly survival-associated TIGD3 data layer compared with 2 for mutation status.

The strongest signal is observed in kidney chromophobe (KICH), where higher TIGD3 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated TIGD3 expression acts as an unfavorable survival marker, although some lineages such as HNSC and LGG show a favorable association.

KICH, HNSC, and LGG are the cancer types where TIGD3 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KICH	OS	Median	II,III,IV	0.882	1.000	.006	82	view →
HNSC	OS	Quartile	All	0.878	0.732	.008	54	view →
LGG	DFS	Median	All	0.881	0.781	<.001	41	view →
SKCM	DFS	Median	II,III,IV	0.655	0.462	<.001	41	view →
LUSC	OS	Median	All	0.475	0.337	.005	37	view →
COAD	DFS	Tertile	II,III,IV	0.345	0.825	.001	37	view →
UVM	DFS	Quartile	All	0.365	0.741	.003	29	view →
LIHC	OS	Tertile	All	0.614	0.794	<.001	29	view →
OV	DFS	Median	III,IV	0.406	0.336	.026	26	view →
ESCA	OS	Median	All	0.418	1.000	.005	25	view →
UCS	DFS	Tertile	IV	0.239	0.942	.024	24	view →
MESO	DFS	Tertile	IV	0.173	0.572	.001	21	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 31 lineages.

TIGD3–KICH (OS)

Open the KICH breakdown →