TIGD3

Across TCGA cell cohorts, TIGD3 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,377 significant associations in total. BONE shows the largest number of these associations.

The most reproducible TIGD3-associated GO terms across cancer lineages are Regulation of double-strand break repair, Mitotic DNA integrity checkpoint signaling, and Positive regulation of DNA recombination. Each is linked with TIGD3 in more than 12 cancer types. Because this analysis shows association rather than direction, both TIGD3-to-partner and partner-to-TIGD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of double-strand break repair grouped by TIGD3-low versus TIGD3-high in BONE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TIGD3→partner) and Y-score (partner→TIGD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BONE	Regulation of double-strand break repair →	+0.070	+0.640	<.001	<.001	3	13
BONE	Mitotic DNA integrity checkpoint signaling →	+0.086	+0.767	<.001	<.001	3	13
BONE	Positive regulation of DNA recombination →	+0.103	+0.679	<.001	<.001	3	13
BONE	Mitotic DNA replication →	+0.236	+0.766	.002	<.001	3	12
BONE	Epigenetic regulation of gene expression →	+0.086	+0.783	.001	<.001	3	12
BLOOD_Myeloma	Regulation of double-strand break repair via homologous recombination →	+0.086	+0.606	.002	<.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,377 associations by consensus.

Regulation of double-strand break repair by TIGD3 expression — BONE

Explore this box plot interactively →