TIGD3

Across TCGA cell cohorts, TIGD3 mutation is significantly associated with the drug of many other genes, with 20 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TIGD3-associated genes across cancer lineages are MCT4_1422, GSK2801, and Ispinesib Mesylate. Each is linked with TIGD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIGD3-to-partner and partner-to-TIGD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MCT4_1422 grouped by TIGD3-low versus TIGD3-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIGD3→partner) and Y-score (partner→TIGD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MCT4_1422 →	+0.273	+2.716	.033	.042	3	1
LARGE_INTESTINE	GSK2801 →	+0.423	+2.649	.007	.046	3	1
LARGE_INTESTINE	Ispinesib Mesylate →	+0.718	+2.652	.027	.045	3	1
LARGE_INTESTINE	CX-5461 →	+0.897	+2.652	.001	.045	3	1
LARGE_INTESTINE	Tenovin-6 →	+0.424	+2.786	.039	.037	3	1
LARGE_INTESTINE	PF-00299804 →	+0.553	+2.652	.018	.045	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

MCT4_1422 by TIGD3 expression — LARGE_INTESTINE

Explore this box plot interactively →