TIGAR

Across TCGA pan-cancer cohorts, TIGAR mass-spec protein is linked to patient survival in 3 of 34 cancer types, making it a survival-associated TIGAR data layer compared with 20 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in colon adenocarcinoma (COAD), where higher TIGAR mass-spec protein is associated with worse disease-free survival. In most high-consensus cancer types, elevated TIGAR expression acts as an unfavorable survival marker.

COAD, LUAD, and GBM are the cancer types where TIGAR mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
COAD	DFS	Median	II,III,IV	0.906	1.000	.008	48	view →
LUAD	OS	Tertile	III,IV	0.399	0.718	.026	6	view →
GBM	DFS	Tertile	All	0.273	0.491	.022	6	view →

Pink = unfavorable, green = favorable. Showing the 3 strongest of 3 lineages.

TIGAR–COAD (DFS)

Open the COAD breakdown →