TIFAB

Across TCGA patient cohorts, TIFAB mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. SKCM shows the largest number of these associations.

The most reproducible TIFAB-associated genes across cancer lineages are Snail, VEGFR2, and p21. Each is linked with TIFAB in more than 1 cancer types. Because this analysis shows association rather than direction, both TIFAB-to-partner and partner-to-TIFAB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Snail grouped by TIFAB-low versus TIFAB-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIFAB→partner) and Y-score (partner→TIFAB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	Snail →	-0.253	-3.000	.010	.036	3	1
UCEC	VEGFR2 →	+0.425	+2.820	.019	.036	3	1
SKCM	p21 →	-0.726	-2.982	.003	.036	1	1
SKCM	p70-S6K →	+0.344	+3.000	.011	.036	1	1
SKCM	PDCD4 →	+0.502	+3.000	.029	.036	1	1
SKCM	Rb →	-0.247	-3.000	.006	.036	1	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Snail by TIFAB expression — SKCM

Explore this box plot interactively →