TIFAB

Across TCGA pan-cancer cohorts, TIFAB RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TIFAB’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TIFAB RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TIFAB is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

KIRC, COAD, and BRCA are the cancer types where TIFAB tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TIFAB RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	IV	+0.477	<.001	12	view →
COAD	Female	II,III,IV	−0.482	<.001	10	view →
BRCA	All	All	+0.283	<.001	4	view →
STAD	Female	All	+0.505	.042	2	view →
LIHC	All	II,III,IV	+0.134	.014	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

TIFAB–KIRC

Open the KIRC breakdown →