TIE1

Across TCGA pan-cancer cohorts, TIE1 Mutation is linked to patient survival in 10 of 34 cancer types, making it a survival-associated TIE1 data layer compared with 25 for mass-spec protein and 2 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher TIE1 Mutation is associated with worse overall survival. In most high-consensus cancer types, elevated TIE1 expression acts as an unfavorable survival marker, although some lineages such as UCEC and GBM show a favorable association.

KIRC, SCLC, and MESO are the cancer types where TIE1 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	II,III,IV	0.134	0.717	.018	18	view →
SCLC	DFS	Median	II,III,IV	0.219	0.609	.017	15	view →
MESO	DFS	Median	III,IV	0.078	0.376	.012	9	view →
LUAD	OS	Median	III,IV	0.172	0.689	.001	9	view →
SKCM	OS	Median	IV	0.297	0.777	<.001	9	view →
UCEC	DFS	Median	All	0.806	0.628	.016	8	view →
SARC	DFS	Median	All	0.161	0.614	.003	6	view →
ESCA	OS	Median	II,III,IV	0.216	0.702	.014	6	view →
GBM	DFS	Median	All	1.000	0.193	.047	3	view →
LIHC	OS	Median	II,III,IV	0.239	0.715	.035	3	view →

Pink = unfavorable, green = favorable. Showing the 10 strongest of 10 lineages.

TIE1–KIRC (OS)

Open the KIRC breakdown →