TIE1

Across TCGA pan-cancer cohorts, TIE1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TIE1’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TIE1 RNA is repressed in tumor relative to normal tissue. In most cancer types TIE1 is over-expressed in tumor, although a few such as LUAD and KIRP show the opposite, repressed pattern.

LUAD, KIRP, and KICH are the cancer types where TIE1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TIE1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Female	All	−1.848	<.001	11	view →
KIRP	Male	All	−2.196	<.001	9	view →
KICH	Male	All	−1.864	<.001	9	view →
LUSC	Female	All	−2.593	<.001	8	view →
HNSC	Female	IV	+2.143	<.001	7	view →
UCEC	All	All	−2.105	<.001	6	view →
BRCA	All	II,III,IV	−1.147	<.001	6	view →
BLCA	Male	All	−1.039	.001	6	view →
STAD	Male	II,III,IV	+1.015	<.001	6	view →
KIRC	Female	All	+0.868	<.001	5	view →
LIHC	Female	All	+0.763	<.001	5	view →
THCA	All	II,III,IV	−0.538	.003	5	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TIE1–LUAD

Open the LUAD breakdown →