TIE1

Across TCGA patient cohorts, TIE1 mutation is significantly associated with the total protein of many other genes, with 51 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIE1-associated genes across cancer lineages are JNK_pT183_Y185, Src_pY416, and Caspase-7-cleavedD198. Each is linked with TIE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TIE1-to-partner and partner-to-TIE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by TIE1-low versus TIE1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIE1→partner) and Y-score (partner→TIE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.122	-1.847	.010	.007	3	3
SKCM	Src_pY416 →	-0.234	-1.459	.018	.011	3	3
COAD	Caspase-7-cleavedD198 →	+1.167	+2.824	.001	.034	3	3
UCEC	4E-BP1 →	+0.229	+1.422	.002	.010	3	3
UCEC	Cyclin-B1 →	+0.568	+2.662	<.001	<.001	3	3
STAD	ER-alpha →	-0.209	-2.094	.001	.017	2	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 51 associations by consensus.

JNK_pT183_Y185 by TIE1 expression — UCEC

Explore this box plot interactively →