TIE1

Across TCGA cell cohorts, TIE1 RNA expression is significantly associated with the go_rna of many other GO terms, with 2,136 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TIE1-associated GO terms across cancer lineages are Regulation of protein localization to mitochondrion, Negative regulation of transcription initiation by RNA polymerase II, and Negative regulation of DNA-templated transcription initiation. Each is linked with TIE1 in more than 6 cancer types. Because this analysis shows association rather than direction, both TIE1-to-partner and partner-to-TIE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of protein localization to mitochondrion grouped by TIE1-low versus TIE1-high in SOFT_TISSUE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TIE1→partner) and Y-score (partner→TIE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SOFT_TISSUE	Regulation of protein localization to mitochondrion →	+0.079	+1.797	<.001	<.001	3	7
LARGE_INTESTINE	Negative regulation of transcription initiation by RNA polymerase II →	+0.113	+0.174	<.001	<.001	3	7
LARGE_INTESTINE	Negative regulation of DNA-templated transcription initiation →	+0.113	+0.174	<.001	<.001	3	7
UPPER_AERODIGESTIVE_TRACT	Golgi disassembly →	+0.110	+0.202	.001	.005	3	7
OVARY	Negative regulation of CD8-positive, alpha-beta T cell differentiation →	-0.139	-1.282	<.001	.009	3	7
UPPER_AERODIGESTIVE_TRACT	Positive regulation of establishment of protein localization →	+0.061	+0.201	<.001	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,136 associations by consensus.

Regulation of protein localization to mitochondrion by TIE1 expression — SOFT_TISSUE

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