TIE1

Across TCGA cell cohorts, TIE1 mutation is significantly associated with the RNA expression of many other genes, with 3,233 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TIE1-associated genes across cancer lineages are YPEL1, SPEF1, and PTOV1. Each is linked with TIE1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TIE1-to-partner and partner-to-TIE1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, YPEL1 grouped by TIE1-low versus TIE1-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIE1→partner) and Y-score (partner→TIE1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	YPEL1 →	+1.688	+3.199	<.001	.007	3	2
BLOOD_Leukemia	SPEF1 →	+0.147	+3.373	.006	.007	3	2
BLOOD_Leukemia	PTOV1 →	+0.651	+3.199	.001	.007	3	2
LARGE_INTESTINE	MED31 →	+0.603	+2.364	.001	<.001	3	2
BLOOD_Leukemia	HPX →	+0.169	+3.438	<.001	.004	3	2
BLOOD_Leukemia	GZMA →	+2.424	+3.438	<.001	.004	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,233 associations by consensus.

YPEL1 by TIE1 expression — BLOOD_Leukemia

Explore this box plot interactively →