TICRR

Across TCGA patient cohorts, TICRR mutation is significantly associated with the RNA expression of many other genes, with 4,874 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TICRR-associated genes across cancer lineages are PPP2R2D, DOC2B, and TMEM269. Each is linked with TICRR in more than 3 cancer types. Because this analysis shows association rather than direction, both TICRR-to-partner and partner-to-TICRR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PPP2R2D grouped by TICRR-low versus TICRR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TICRR→partner) and Y-score (partner→TICRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PPP2R2D →	+0.202	+3.150	.004	<.001	3	4
UCEC	DOC2B →	-0.755	-1.694	<.001	.003	3	3
UCEC	TMEM269 →	+0.126	+1.961	<.001	<.001	3	3
UCEC	SAPCD2 →	+0.522	+2.403	<.001	<.001	3	3
UCEC	MKRN2OS →	+0.529	+1.959	<.001	<.001	3	3
UCEC	SLC26A6 →	+0.345	+1.572	.003	.004	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,874 associations by consensus.

PPP2R2D by TICRR expression — UCEC

Explore this box plot interactively →