TICRR

Across TCGA patient cohorts, TICRR mutation is significantly associated with the total protein of many other genes, with 49 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TICRR-associated genes across cancer lineages are TIGAR, MEK1, and ASNS. Each is linked with TICRR in more than 2 cancer types. Because this analysis shows association rather than direction, both TICRR-to-partner and partner-to-TICRR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TIGAR grouped by TICRR-low versus TICRR-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TICRR→partner) and Y-score (partner→TICRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	TIGAR →	+0.108	+1.884	.016	<.001	3	3
SKCM	MEK1 →	+0.517	+3.000	.011	.036	3	2
COAD	ASNS →	+0.881	+3.008	<.001	.019	3	2
COAD	ATM →	-0.671	-2.991	<.001	.036	3	2
UCEC	FOXO3a_pS318_S321 →	-0.095	-1.449	.010	.011	3	2
UCEC	MSH2 →	-0.211	-1.558	.001	.015	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 49 associations by consensus.

TIGAR by TICRR expression — UCEC

Explore this box plot interactively →