TICRR

Across TCGA cell cohorts, TICRR mutation is significantly associated with the RNA expression of many other genes, with 1,257 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TICRR-associated genes across cancer lineages are PAFAH2, FREM3, and TBL2. Each is linked with TICRR in more than 1 cancer types. Because this analysis shows association rather than direction, both TICRR-to-partner and partner-to-TICRR results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PAFAH2 grouped by TICRR-low versus TICRR-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TICRR→partner) and Y-score (partner→TICRR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PAFAH2 →	+0.605	+3.321	<.001	.003	3	2
LUNG_NSCLC_LUAD	FREM3 →	+0.090	+3.612	.002	.004	3	2
LARGE_INTESTINE	TBL2 →	+0.657	+3.482	<.001	<.001	3	2
LARGE_INTESTINE	EIF2B4 →	+0.448	+2.502	<.001	.005	3	2
LARGE_INTESTINE	TXNDC12 →	+0.459	+3.082	.002	.007	3	2
LARGE_INTESTINE	RWDD2A →	+0.602	+3.321	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,257 associations by consensus.

PAFAH2 by TICRR expression — SKIN

Explore this box plot interactively →