TIAM2

Across TCGA cell cohorts, TIAM2 mutation is significantly associated with the RNA expression of many other genes, with 871 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TIAM2-associated genes across cancer lineages are GSG1L2, ZIC5, and EIF3L. Each is linked with TIAM2 in more than 2 cancer types. Because this analysis shows association rather than direction, both TIAM2-to-partner and partner-to-TIAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GSG1L2 grouped by TIAM2-low versus TIAM2-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIAM2→partner) and Y-score (partner→TIAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	GSG1L2 →	+0.088	+3.215	<.001	<.001	3	2
LARGE_INTESTINE	ZIC5 →	+1.158	+2.628	<.001	.002	3	2
LARGE_INTESTINE	EIF3L →	+0.537	+3.389	<.001	.001	3	2
LARGE_INTESTINE	CNIH1 →	+0.478	+2.714	.001	.002	2	3
LARGE_INTESTINE	PPP2R5D →	+0.700	+3.386	<.001	.001	3	2
LARGE_INTESTINE	MRPS27 →	+0.637	+2.628	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 871 associations by consensus.

GSG1L2 by TIAM2 expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →