TIA1

Across TCGA pan-cancer cohorts, TIA1 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TIA1 data layer compared with 23 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TIA1 mass-spec protein is associated with worse overall survival. In most high-consensus cancer types, elevated TIA1 expression acts as an unfavorable survival marker, although some lineages such as LUAD and LSCC show a favorable association.

HNSC, LUAD, and LSCC are the cancer types where TIA1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Tertile	IV	0.591	0.965	<.001	29	view →
LUAD	DFS	Tertile	II,III,IV	0.939	0.742	.004	18	view →
LSCC	OS	Median	II,III,IV	1.000	0.885	.022	4	view →
CCRCC	OS	Median	III,IV	0.803	0.960	.033	1	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TIA1–HNSC (OS)

Open the HNSC breakdown →