TIA1

Across TCGA pan-cancer cohorts, TIA1 RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of TIA1’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where TIA1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TIA1 is over-expressed in tumor, although a few such as KICH show the opposite, repressed pattern.

BLCA, HNSC, and KIRC are the cancer types where TIA1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TIA1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	All	All	+0.885	<.001	10	view →
HNSC	All	III,IV	+0.712	<.001	10	view →
KIRC	All	All	+0.441	<.001	10	view →
LIHC	All	II,III,IV	+0.882	<.001	8	view →
KICH	Female	All	−1.527	<.001	7	view →
COAD	All	II,III,IV	+0.731	<.001	7	view →
CHOL	Male	All	+2.343	<.001	5	view →
READ	All	All	+0.643	.005	5	view →
STAD	All	II,III,IV	+0.804	.008	4	view →
LUSC	All	All	+0.540	<.001	4	view →
LUAD	All	All	+0.415	.001	3	view →
ESCA	All	All	+0.641	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

TIA1–BLCA

Open the BLCA breakdown →