TIA1

Across TCGA patient cohorts, TIA1 protein abundance is significantly associated with the RNA expression of many other genes, with 18,810 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible TIA1-associated genes across cancer lineages are GPC2, WDCP, and UCK2. Each is linked with TIA1 in more than 7 cancer types. Because this analysis shows association rather than direction, both TIA1-to-partner and partner-to-TIA1 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TIA1 versus GPC2 in LSCC, with a Pearson correlation of 0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIA1→partner) and Y-score (partner→TIA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LSCC	GPC2 →	+1.038	+0.249	<.001	.005	3	8
HNSC	WDCP →	+0.814	+0.372	<.001	<.001	3	7
UCEC	UCK2 →	+1.020	+0.394	<.001	<.001	3	6
HNSC	ZNF3 →	+0.600	+0.248	<.001	<.001	3	6
HNSC	USP39 →	+0.709	+0.297	.002	<.001	3	6
HNSC	FAM136A →	+0.640	+0.261	.004	.002	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 18,810 associations by consensus.

TIA1 vs GPC2 — LSCC

Explore this scatter interactively →