TIA1

Across TCGA patient cohorts, TIA1 mutation is significantly associated with the total protein of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TIA1-associated genes across cancer lineages are Caspase-7-cleavedD198, FoxM1, and Annexin-1. Each is linked with TIA1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TIA1-to-partner and partner-to-TIA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Caspase-7-cleavedD198 grouped by TIA1-low versus TIA1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TIA1→partner) and Y-score (partner→TIA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Caspase-7-cleavedD198 →	+0.559	+3.479	.022	.002	3	2
UCEC	FoxM1 →	+0.214	+2.321	.045	.006	3	1
UCEC	Annexin-1 →	+0.458	+3.341	.035	.005	3	1
UCEC	ASNS →	+0.332	+2.321	.026	.034	3	1
UCEC	Caspase-8 →	-0.234	-3.432	.024	.005	3	1
UCEC	p27_pT198 →	+0.090	+1.807	.040	.027	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Caspase-7-cleavedD198 by TIA1 expression — UCEC

Explore this box plot interactively →