TIA1

Across TCGA cell cohorts, TIA1 RNA expression is significantly associated with the go_rna of many other GO terms, with 5,593 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TIA1-associated GO terms across cancer lineages are Protein localization to cytoplasmic stress granule, Positive regulation of double-strand break repair, and mRNA splice site recognition. Each is linked with TIA1 in more than 19 cancer types. Because this analysis shows association rather than direction, both TIA1-to-partner and partner-to-TIA1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Protein localization to cytoplasmic stress granule grouped by TIA1-low versus TIA1-high in URINARY_TRACT.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TIA1→partner) and Y-score (partner→TIA1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
URINARY_TRACT	Protein localization to cytoplasmic stress granule →	+0.160	+1.067	<.001	<.001	3	20
BONE	Positive regulation of double-strand break repair →	+0.102	+0.911	<.001	.003	3	18
OVARY	mRNA splice site recognition →	+0.129	+0.793	<.001	<.001	3	18
BONE	Regulation of organelle assembly →	+0.053	+1.080	<.001	<.001	3	17
BONE	Late viral transcription →	+0.147	+0.958	.004	.003	3	17
LUNG_SCLC	Negative regulation of telomere maintenance →	+0.086	+0.963	<.001	<.001	3	17

Each partner links to its Q-omics profile. Showing the 6 strongest of 5,593 associations by consensus.

Protein localization to cytoplasmic stress granule by TIA1 expression — URINARY_TRACT

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