THUMPD3

Across TCGA patient cohorts, THUMPD3 protein abundance is significantly associated with the RNA expression of many other genes, with 14,699 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible THUMPD3-associated genes across cancer lineages are VHL, CHCHD4, and FANCD2. Each is linked with THUMPD3 in more than 7 cancer types. Because this analysis shows association rather than direction, both THUMPD3-to-partner and partner-to-THUMPD3 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, THUMPD3 versus VHL in OV, with a Pearson correlation of 0.40.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THUMPD3→partner) and Y-score (partner→THUMPD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OV	VHL →	+0.453	+0.319	.001	<.001	3	8
OV	CHCHD4 →	+0.518	+0.295	<.001	<.001	3	7
LSCC	FANCD2 →	+0.805	+0.309	<.001	<.001	3	6
LSCC	CNOT10 →	+0.509	+0.304	<.001	<.001	3	6
LSCC	RAD18 →	+0.680	+0.344	<.001	<.001	3	6
UCEC	LSM3 →	+0.662	+0.287	<.001	<.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 14,699 associations by consensus.

THUMPD3 vs VHL — OV

Explore this scatter interactively →