THUMPD3

Across TCGA pan-cancer cohorts, THUMPD3 RNA differs between tumor and matched normal tissue in 15 of 18 cancer types tested, making tumor–normal expression one of THUMPD3’s most consistent transcriptional readouts.

The strongest signal is observed in liver hepatocellular carcinoma (LIHC), where THUMPD3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types THUMPD3 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

LIHC, LUAD, and COAD are the cancer types where THUMPD3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in THUMPD3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LIHC	Female	II,III,IV	+1.049	<.001	9	view →
LUAD	Male	All	+0.552	<.001	9	view →
COAD	Male	All	+0.502	<.001	9	view →
STAD	All	II,III,IV	+0.657	<.001	7	view →
KIRC	Male	II,III,IV	−0.439	<.001	7	view →
BLCA	All	All	+0.617	.001	6	view →
BRCA	All	III,IV	+0.576	<.001	6	view →
THCA	All	II,III,IV	−0.274	.011	6	view →
KIRP	Female	II,III,IV	+0.759	.001	5	view →
LUSC	Male	All	+0.374	<.001	5	view →
UCEC	All	III,IV	+0.604	.013	4	view →
CHOL	All	All	+1.190	<.001	3	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 15 lineages.

THUMPD3–LIHC

Open the LIHC breakdown →