THUMPD3

Across TCGA patient cohorts, THUMPD3 mutation is significantly associated with the RNA expression of many other genes, with 1,241 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THUMPD3-associated genes across cancer lineages are RRM2P4, RPS10P21, and RNU7-105P. Each is linked with THUMPD3 in more than 1 cancer types. Because this analysis shows association rather than direction, both THUMPD3-to-partner and partner-to-THUMPD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RRM2P4 grouped by THUMPD3-low versus THUMPD3-high in CESC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THUMPD3→partner) and Y-score (partner→THUMPD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CESC	RRM2P4 →	+0.074	+5.539	<.001	.004	3	2
BRCA	RPS10P21 →	+0.145	+5.441	<.001	.005	3	2
HNSC	RNU7-105P →	+0.568	+7.954	<.001	.008	3	2
READ	MIR6885 →	+0.479	+5.257	<.001	.002	3	2
BLCA	RNA5SP333 →	+0.182	+4.618	<.001	.005	3	2
COAD	MTCO3P16 →	+0.203	+5.893	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,241 associations by consensus.

RRM2P4 by THUMPD3 expression — CESC

Explore this box plot interactively →