THUMPD3

Across TCGA patient cohorts, THUMPD3 mutation is significantly associated with the total protein of many other genes, with 37 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible THUMPD3-associated genes across cancer lineages are Shc_pY317, AMPK_pT172, and ATM. Each is linked with THUMPD3 in more than 2 cancer types. Because this analysis shows association rather than direction, both THUMPD3-to-partner and partner-to-THUMPD3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Shc_pY317 grouped by THUMPD3-low versus THUMPD3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (THUMPD3→partner) and Y-score (partner→THUMPD3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Shc_pY317 →	-0.129	-1.584	.030	.036	3	3
UCEC	AMPK_pT172 →	+0.350	+1.598	.030	.022	3	2
UCEC	ATM →	-0.443	-2.321	.012	.034	3	2
UCEC	Bcl-2 →	-0.436	-3.459	.001	.005	3	2
UCEC	Di-Ras3 →	-0.184	-2.502	.001	.002	3	2
UCEC	14-3-3_beta →	-0.139	-2.673	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 37 associations by consensus.

Shc_pY317 by THUMPD3 expression — UCEC

Explore this box plot interactively →